System of Combination of various Rate controlling polymers, gives desirable drug release pattern
Two different viscosity grades available
Diffusion controlled release pattern
Substantial HPMC K is difficult to granulate and mill
Conventionally, development of sustained release formulation involves granulation of polymer with API to provide intimate mixing, SR300 and SR301 gives process ease and develop formulation with DC
Chemical Name: Microcrystalline cellulose – 25 to 35% Ethylcellulose – 1 to 4 %, Hydroxypropyl methyl cellulose K4M – 50 to 60 %, Hydroxypropyl cellulose – 1 to 3 %, Colloidal Silicon Dioxide – 0.4 to 0.8 %, Maize Starch – 5 to 12 %, Magnesium Stearate – 0.3 to 0.7 %, Talc – 0.2 to 1 %