Croscarmellose Sodium (CCS) is a cross-linked polymer of carboxymethylcellulose sodium and is widely used as a superdisintegrant in pharmaceutical formulations. It enhances the disintegration and dissolution of tablets, capsules, and other solid dosage forms, making it essential for fast and effective drug delivery.
Key Features
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Superdisintegrant
Facilitates rapid tablet Disintegrants in aqueous environments, ensuring faster drug release. -
High Water Wicking Capacity
Swells upon contact with water, exerting mechanical pressure for quick disintegration. -
Non-Iconic and Stable
Chemically stable across a wide pH range (1.2–10). -
Efficient Low Usage Levels
Effective at concentrations as low as 0.5%–5% w/w of the tablet weight. -
Versatile Compatibility
Suitable for both immediate-release (IR) and orally disintegrating tablets (ODTs).
Applications
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Immediate-Release
Tablets Enhances drug release for quicker therapeutic effects.
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Orally Disintegrating Tablets (ODTs)
Ideal for formulations where rapid disintegration in the mouth is critical.
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Capsules
Improves capsule disintegration in gastrointestinal fluids.
Regulatory Complaince
- USP-NF • BP • IP • EP
- DMF
- EXCiPAT
- KOSHER
- HALAL
- WHO-GMP