Hydroxypropyl Beta Cyclodextrin (HP-β-CD) is a water-soluble derivative of Beta Cyclodextrin, widely used as a complexing agent in pharmaceutical formulations. It enhances the solubility, stability, and bioavailability of poorly soluble drugs, making it an essential excipient for modern drug delivery systems
Key Features
- Improved Solubility Forms inclusion complexes with hydrophobic drugs, significantly enhancing solubility.
- Enhanced Stability Protects sensitive APIs from light, heat, & oxidation.
- Biocompatibility Non-toxic and non-irritating, suitable for parenteral, oral, and topical applications.
- Wide pH Range Effective across a broad pH range (3–12).
- Low Hemolytic Activity Safer than other cyclodextrin derivatives for intravenous use.
Applications
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Oral Drug Delivery
Improves solubility and taste masking of APIs.
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Injectable Formulations
Solubilizes hydrophobic drugs for parenteral administration.
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Topical and Ophthalmic Formulations
Enhances the penetration and stability of active ingredients.
Regulatory Complaince
- USP-NF • BP • IP • EP
- DMF
- EXCiPAT
- KOSHER
- HALAL
- WHO-GMP